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Hence, cell\u2010membrane\u2010derived nanoparticles (CMNPs) are produced using tonsil\u2010derived mesenchymal stem cells (TMSCs) from children owing to their short doubling time. As target cell types, laryngeal cancer cells are compared to\u00a0bone\u2010marrow\u2010derived MSCs (BMSCs) because of their cartilage damaging and chondrogenic characteristics, respectively. Treating spheroids of these cell types with CMNPs exacerbates\u00a0interspheroid\u00a0hypoxia with robust maintenance of the cell\u2013cell interaction signature for 7 days. Both cell types prefer a hypoxic environment, as opposed to blood vessel formation that is absent in cartilage but is required for cancer growth. Hence, angiogenesis is inhibited by displaying the Notch\u20101 aptamer on CMNPs. Consequently, laryngeal cancer growth is suppressed efficiently in contrast to improved chondroprotection observed in a series of cell and animal experiments using a xenograft mouse model of laryngeal cancer.\u00a0Altogether, CMNPs execute\u00a0a two\u2010edged sword function of\u00a0inducing hypoxic cell\u2013cell packing, followed by suppressing angiogenesis to promote\u00a0laryngeal cancer death and chondrogenesis\u00a0simultaneously.\u00a0This study presents a previously unexplored therapeutic strategy for anti\u2010cancer and chondroprotective treatment using CMNPs.<\/jats:p>","DOI":"10.1002\/adma.202101558","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T05:18:07Z","timestamp":1629868687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cell\u2010Membrane\u2010Derived Nanoparticles with Notch\u20101 Suppressor Delivery Promote Hypoxic Cell\u2013Cell Packing and 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