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Microwave (MW) dynamic therapy is attracting attention due to its excellent penetration ability, but the mechanism of MW\u2010induced reactive oxygen species (ROS) is still unknown. Herein, MW\u2010responsive engineered pseudo\u2010macrophages (M\u2010Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\/Au nanoparticles (NPs)) are fabricated to clear <jats:italic>Staphylococcus aureus<\/jats:italic> infections and induce M2 polarization of macrophages to improve osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) under MW irradiation. Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\/Au NPs can generate <jats:bold>\u00b7<\/jats:bold>O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> and heat under MW irradiation in a saline solution, and the mechanism is put forward via finite element modeling and density functional theory calculations. Due to the gap plasmon, electromagnetic hotspots are produced at Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2013Au interface at 2.45\u00a0GHz. Because of these induced electromagnetic hotspots, the sodium species is field\u2010ionized and subsequently reacts with oxygen to produce <jats:bold>\u00b7<\/jats:bold>O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup>. Meanwhile, the Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\/Au NPs have a stronger ability than Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> NPs to fix oxygen, favoring the production of ROS. Additionally, MW\u2010treated macrophages diminish to secrete inflammatory cytokines, resulting in the decrease of ROS production in MSCs and thus enhancing their osteogenic differentiation. These engineered pseudo\u2010macrophages will be promising for effectively treating bacterial infections and promoting osteoblast differentiation simultaneously in deep tissues under MW irradiation.<\/jats:p>","DOI":"10.1002\/adma.202102926","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:50:18Z","timestamp":1629075018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["An Engineered Pseudo\u2010Macrophage for Rapid Treatment of Bacteria\u2010Infected Osteomyelitis via Microwave\u2010Excited Anti\u2010Infection and Immunoregulation"],"prefix":"10.1002","volume":"33","author":[{"given":"Jieni","family":"Fu","sequence":"first","affiliation":[{"name":"School of Materials Science &amp; Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin University  Tianjin 300072 P. R. 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