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Herein, three boron dipyrromethene (BODIPY) dyes are synthesized to demonstrate that anthracence\u2010functionalized BODIPY, namely ABDPTPA is an efficient heavy\u2010atom\u2010free photosensitizer for the reversible capture and release of\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . The spin\u2013orbit charge\u2010transfer intersystem crossing of ABDPTPA promises a high\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    quantum yield of 60% in dichloromethane. Under light irradiation, the anthracene group reacts with\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to produce endoperoxide. Interestingly, after termination of irradiation, the endoperoxide undergoes thermal cycloreversion to produce\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , and regenerates the anthracene module to achieve\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u201cafterglow,\u201d which results in a prolonged half lifetime of\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    for 9.2\u00a0min. In vitro cytotoxicity assays indicate that ABDPTPA nanoparticles have a low half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 3.6\u00a0\u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    on U87MG cells. Further, the results of near\u2010infrared\u2010II fluorescence\u2010imaging\u2010guided phototherapy indicate that ABDPTPA nanoparticles can inhibit tumor proliferation even at a low dose (200\u00a0\u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 100\u00a0\u00b5L) without any side effects. Therefore, the study provides a generalized\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u201cafterglow\u201d strategy to enhance phototheranostics for complete tumor regression.\n                  <\/jats:p>","DOI":"10.1002\/adma.202103627","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T05:53:17Z","timestamp":1631512397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["Singlet Oxygen \u201cAfterglow\u201d Therapy with NIR\u2010II Fluorescent Molecules"],"prefix":"10.1002","volume":"33","author":[{"given":"Jianhua","family":"Zou","sequence":"first","affiliation":[{"name":"Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore  Singapore 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