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Activation of the cyclic guanosine monophosphate\u2010adenosine monophosphate synthase\/interferon gene stimulator (cGAS\/STING) signaling pathway to upregulate innate immunity has become an emerging strategy for enhancing tumor immunotherapy. Herein, ZnS@BSA (bovine serum albumin) nanoclusters synthesized via a self\u2010assembly approach are reported, where the released zinc ions under acidic tumor microenvironment significantly enhance cGAS\/STING signals. Meanwhile, intracellular zinc ions can produce reactive oxygen species, which is further facilitated by the generated H\n                    <jats:sub>2<\/jats:sub>\n                    S gas from ZnS@BSA via specifically inhibiting catalase in hepatocellular carcinoma cells. It is found that the nanoclusters activate the cGAS\/STING signals in mice, which promotes the infiltration of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells at the tumor site and cross\u2010presentation of dendritic cells, leading to an improved immunotherapy efficacy against hepatocellular carcinoma.\n                  <\/jats:p>","DOI":"10.1002\/adma.202104037","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T18:50:34Z","timestamp":1633805434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":190,"title":["ZnS@BSA Nanoclusters Potentiate Efficacy of Cancer Immunotherapy"],"prefix":"10.1002","volume":"33","author":[{"given":"Dong","family":"Cen","sequence":"first","affiliation":[{"name":"Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 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