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However, combining upscalable manufacturing with the required performance remains challenging. Here, an alternative biosensor transistor concept is developed, which relies on a solution\u2010processed In<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>\/ZnO semiconducting heterojunction featuring a geometrically engineered tri\u2010channel architecture for the rapid, real\u2010time detection of important biomolecules. The sensor combines a high electron mobility channel, attributed to the electronic properties of the In<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>\/ZnO heterointerface, in close proximity to a sensing surface featuring tethered analyte receptors. The unusual tri\u2010channel design enables strong coupling between the buried electron channel and electrostatic perturbations occurring during receptor\u2013analyte interactions allowing for robust, real\u2010time detection of biomolecules down to attomolar (a<jats:sc>m<\/jats:sc>) concentrations. The experimental findings are corroborated by extensive device simulations, highlighting the unique advantages of the heterojunction tri\u2010channel design. By functionalizing the surface of the geometrically engineered channel with severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) antibody receptors, real\u2010time detection of the SARS\u2010CoV\u20102 spike S1 protein down to a<jats:sc>m<\/jats:sc> concentrations is demonstrated in under 2 min in physiological relevant conditions.<\/jats:p>","DOI":"10.1002\/adma.202104608","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T21:40:10Z","timestamp":1636062010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Tri\u2010Channel Oxide Transistor Concept for the Rapid Detection of Biomolecules Including the SARS\u2010CoV\u20102 Spike Protein"],"prefix":"10.1002","volume":"34","author":[{"given":"Yen\u2010Hung","family":"Lin","sequence":"first","affiliation":[{"name":"Blackett Laboratory Department of Physics Imperial College London  London SW7 2AZ 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