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However, the shear forces during direct injection and the harsher shear condition of OA environments would lead to significant cell damage and inhibit the therapeutic efficacy. Herein, DNA supramolecular hydrogel has been applied as delivering material for MSCs to treat severe OA model, which perform extraordinary protection in MSCs against the shear force both in vitro and in vivo. It is demonstrated that the DNA supramolecular hydrogel can promote formation of quality cartilage, reduce osteophyte, and normalize subchondral bone under the high friction condition of OA, whose molecular mechanisms underlying therapeutic effects are also investigated. It can be anticipated that DNA supramolecular hydrogel would be a promising cell delivery system for multiple potential MSCs therapy.<\/jats:p>","DOI":"10.1002\/adma.202104758","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T15:54:56Z","timestamp":1634658896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["Anti\u2010Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis"],"prefix":"10.1002","volume":"33","author":[{"given":"Xin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital  Beijing 100191 China"},{"name":"Institute of Sports Medicine Peking University  Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorus Chemistry &amp; 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