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Here, novel magneto\u2010responsive microneedle robots are presented for efficient oral delivery of versatile macromolecules. These microneedle robots with three components of the magnetic substrate, the separable connection, and tips are generated by a Lego\u2010brick\u2010stacking\u2010inspired multistage 3D fabrication strategy. With the assistance of commercial enteric capsule encapsulation, they can be taken orally and be released when entering the small intestine. Benefitting from their polarized magnetic substrate, the tips of the microneedle robots can orient to the small intestinal wall, overcome the barriers, insert into the tissue, and deliver encapsulated actives under specific magnetic fields. Besides, after the separable connection degrades, the tips can be left inside the tissue for continuous actives release, and the magnetic substrate can be excreted safely. Based on these features, the practical values of the microneedle robots are demonstrated by using them to orally deliver insulin and efficiently regulate the blood glucose of pigs. It is believed that the proposed microneedle robots can orally deliver diverse macromolecules and thus open a new chapter for oral administration.<\/jats:p>","DOI":"10.1002\/adma.202104932","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T03:08:31Z","timestamp":1631848111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":237,"title":["Magneto\u2010Responsive Microneedle Robots for Intestinal Macromolecule Delivery"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-6558","authenticated-orcid":false,"given":"Xiaoxuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210002 China"},{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guopu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing 210002 China"},{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"},{"name":"Chemistry and Biomedicine Innovation Center Nanjing University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau2277"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba8014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3627"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.101019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0156-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008879"},{"key":"e_1_2_9_7_1","volume":"2020","author":"Li G. 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