{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:21:16Z","timestamp":1789597276567,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030050"],"award-info":[{"award-number":["82030050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fast and effective thrombolysis using tissue plasminogen activator (tPA) is limited by the poor delivery efficiency of thrombolytic drugs, which is induced by an interrupted bloodstream and delayed recanalization. Existing magnetic micro\/nanodrug\u2010loaded robots used for targeted thrombotic therapy are limited by the complexity of the clinical verification of nanodrugs and the limited space of magnetic actuation systems. Herein, a general drug delivery strategy based on mass transportation theory for thrombolysis is presented, and an open space C\u2010shaped magnetic actuation system with laser location and ultrasound imaging navigation for in vivo evaluation is developed. tPA can be guided through an interrupted bloodstream to the thrombi by the locomotion of magnetic nanoparticle swarms (MNSs), thereby improving the thrombolysis efficacy. Notably, this strategy is able to quickly establish a life channel to achieve time\u2010critical recanalization, which is typically inaccessible using native tPA. Both in vitro and in vivo thrombolysis experiments demonstrate that the thrombus lysis efficacy significantly increases after the application of the MNS under a rotating magnetic field. This study provides an anticipated C\u2010shaped magnetic actuation system for in vivo validation and also presents a clinically feasible drug delivery strategy for targeted thrombolytic therapy with minimal systemic tPA exposure.<\/jats:p>","DOI":"10.1002\/adma.202105351","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T14:50:21Z","timestamp":1634482221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Guiding Drug Through Interrupted Bloodstream for Potentiated Thrombolysis by C\u2010Shaped Magnetic Actuation System In Vivo"],"prefix":"10.1002","volume":"33","author":[{"given":"Longchen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jienan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnian","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Dong","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University  199 Ren'ai Road Suzhou Jiangsu 215123 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-3746","authenticated-orcid":false,"given":"Jianrong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"},{"name":"Shanghai Center for Brain Science and Brain\u2010Inspired Technology  Shanghai 200031 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai 200030 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangzhu","family":"Feng","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University  199 Ren'ai Road Suzhou Jiangsu 215123 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-1039","authenticated-orcid":false,"given":"Zhuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University  199 Ren'ai Road Suzhou Jiangsu 215123 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-0641","authenticated-orcid":false,"given":"Yuanyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital  No. 600 Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6983"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0118-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2018.1384464"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0292"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00825-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217815"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011063"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2009.08.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4973857"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201701824"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901378"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201901176"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2007.05.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01234"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaz9519"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aay6626"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aba5726"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13576-6"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aisy.202000267"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c09939"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201905145"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000366"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08587"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b14790"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-016-1152-4"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz8204"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b09423"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120297"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn5029955"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav4803"},{"key":"e_1_2_8_34_1","volume-title":"Proc. IEEE Int. Conf. on Robotics and Automation (ICRA)","author":"Yu J.","year":"2017"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1109\/LRA.2021.3068978"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.041"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400407a"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC07149C"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007356"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201806340"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aav8006"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe5914"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202105351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202105351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202105351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:21:52Z","timestamp":1759789312000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202105351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,13]]},"references-count":42,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/adma.202105351"],"URL":"https:\/\/doi.org\/10.1002\/adma.202105351","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,13]]},"assertion":[{"value":"2021-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2105351"}}