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However, the existing biomaterial scaffold\u2010mediated systems remain limited in efficient uterus recovery, leading to low pregnancy rate and live births. Here, reconstructable uterus\u2010derived materials (RUMs) are demonstrated by combining uterus\u2010derived extracellular matrix and seeded chorionic villi mesenchymal stem cells for uterus recovery, achieving highly efficient live births in rats with severe uterine injury. The RUMs can be designed into different states (such as, liquid RUMs and solid RUMs) and shapes (such as, cuboid, triangular\u2010prism, and cube) in terms of requirements. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction, as well as, accelerate wound healing by constructing a physical barrier and secreting cytokines, allowing efficient uterus recovery. The injured uterus nearly achieves complete recovery after treating with the RUMs and has normal pregnancies for supporting fetal development and live births, similar to the normal rats. The study provides a regenerative medicine therapeutics for uterine factor infertility.<\/jats:p>","DOI":"10.1002\/adma.202106510","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T21:27:57Z","timestamp":1638394077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Reconstructable Uterus\u2010Derived Materials for Uterus Recovery toward Efficient Live Births"],"prefix":"10.1002","volume":"34","author":[{"given":"Xiao","family":"Yi","sequence":"first","affiliation":[{"name":"Research Centre for Artificial Organ and Tissue Engineering &amp; Institute of Regenerative Medicine Department of Hepatobiliary Surgery II Zhujiang Hospital Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou Guangdong Province 510280 P. R. China"},{"name":"Department of Gynecology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gynecology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Zhujiang Hospital Southern Medical University  Guangzhou Guangdong Province P. R. 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