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Apart from imperfect antibacterial therapies, induction of insufficient immunogenicity, required for the successful clearance of a pathogen, may also contribute to the problem. Herein, an ultra\u2010micro photosensitizer, AgB nanodots, using photothermal therapy, photodynamic therapy, and Ag<jats:sup>+<\/jats:sup> ion sterilization, are utilized to efficiently clear invading MRSA both in vitro and in vivo. AgB nanodots are also found to upregulate host immunogenicity in a murine model and establish immunological memory by promoting the upregulated expression of danger signals that are commonly induced by stress\u2010related responses, including sudden temperature spikes or excess reactive oxygen production. These stimulations boost the antibacterial effects of macrophages, dendritic cells, T cells, or even memory B cells, which is usually defined as infection\u2010related immunogenic cell death. Hence, the proposed AgB nanodot strategy may offer a novel platform for the effective treatment of postoperative infection while providing a systematic immunotherapeutic strategy to combat persistent infections, thereby markedly reducing the incidence of recurrence following recovery from primary infections.<\/jats:p>","DOI":"10.1002\/adma.202107300","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T16:10:12Z","timestamp":1638720612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Photosensitizer Nanodot Eliciting Immunogenicity for Photo\u2010Immunologic Therapy of Postoperative Methicillin\u2010Resistant <i>Staphylococcus aureus<\/i> Infection and Secondary Recurrence"],"prefix":"10.1002","volume":"34","author":[{"given":"Haozheng","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Bone and Joint Surgery Department of Orthopedics Renji Hospital Shanghai Jiao Tong University School of Medicine  145 Shandong Middle Road Shanghai 200001 P. 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