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However, it is still challenging to further enhance their biocatalytic performances due to the limited strategies to tune the electronic structures of active centers. Here, a new path is reported for the de novo design of the d electrons of active centers by modulating the electron transfer in vanadium\u2010based AEs (VO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010AE) via a unique Zn\u2013O\u2013V bridge for efficient reactive oxygen species (ROS)\u2010catalysis. Benefiting from the electron transfer from Zn to V, the V site in VO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010AE exhibits a lower valence state than that in V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    , which results in charge\u2010filled V\u2010d\n                    <jats:italic>\n                      <jats:sub>yz<\/jats:sub>\n                    <\/jats:italic>\n                    orbital near the Fermi level to interfere with the formation of sigma bonds between the V\u2010 and O\u2010p\n                    <jats:italic>\n                      <jats:sub>z<\/jats:sub>\n                    <\/jats:italic>\n                    orbitals in H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . The VO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010AE exhibits a twofold\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    and threefold turnover number than V\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>5<\/jats:sub>\n                    when catalyzing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Meanwhile, the VO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010AE shows enhanced catalytic eradication of drug\u2010resistant bacteria and achieves comparable wound\u2010treatment indexes to vancomycin. This modulating charge\u2010filling of d electrons provides a new direction for the de novo design of nanomaterials\u2010based AEs and deepens the understanding of ROS\u2010catalysis.\n                  <\/jats:p>","DOI":"10.1002\/adma.202108646","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T01:51:05Z","timestamp":1645235465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Modulating Electron Transfer in Vanadium\u2010Based Artificial Enzymes for Enhanced ROS\u2010Catalysis and Disinfection"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-236X","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound College of Polymer Science and Engineering National Clinical Research Center for Geriatrics Med\u2010X Center for Materials West China Hospital Sichuan University  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