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Herein, immuno\u2010engineered nanodecoys (NDs) based on poly(lactic\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid) nanoparticles coated with programmed death\u2010ligand 1 (PD\u2010L1)\u2010expressing macrophage membrane (PRM) are developed to mediate multi\u2010target interruption of the self\u2010promoted inflammatory cascade in AIDs. The PRM collected from IFN\u2010\u03b3\u2010treated RAW 264.7 cells possesses elevated surface levels of adhesion molecule receptors and pro\u2010inflammatory cytokine receptors, and, thus, systemically administered PRM NDs afford higher accumulation level in inflamed tissues and stronger scavenging efficiency toward multiple pro\u2010inflammatory cytokines. More importantly, IFN\u2010\u03b3 treatment induces remarkable PD\u2010L1 expression on PRM, thereby allowing PRM NDs to bind membrane\u2010bound programmed death\u20101 (PD\u20101) on CD4<jats:sup>+<\/jats:sup> T cell surfaces or neutralize free soluble PD\u20101, which reconstructs the PD\u20101\/PD\u2010L1 inhibitory axis to suppress CD4<jats:sup>+<\/jats:sup> T cell activation and restore immune tolerance. As such, PRM NDs provoke potent and cooperative anti\u2010inflammatory and immune\u2010suppressive efficacies to alleviate autoimmune damages in Zymosan A\u2010induced arthritis mice and dextran sulfate sodium\u2010induced ulcerative colitis mice. This study provides an enlightened example for the immuno\u2010engineering of cell\u2010membrane\u2010based NDs, rendering promising implications into the treatment of AIDs via multi\u2010target immune\u2010modulation.<\/jats:p>","DOI":"10.1002\/adma.202108817","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T08:08:43Z","timestamp":1642579723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Immuno\u2010Engineered Nanodecoys for the Multi\u2010Target Anti\u2010Inflammatory Treatment of Autoimmune Diseases"],"prefix":"10.1002","volume":"34","author":[{"given":"Mengying","family":"Hou","sequence":"first","affiliation":[{"name":"Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials and Devices Soochow University  Suzhou 215123 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