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However, clinical meshes fail to achieve anti\u2010deformation, anti\u2010adhesion, and pro\u2010healing properties simultaneously, leading to undesirable surgery outcomes. Herein, inspired by the peritoneum, a novel biocompatible Janus porous poly(vinyl alcohol) hydrogel (JPVA hydrogel) is developed to achieve efficient repair of internal soft\u2010tissue defects by a facile yet efficient strategy based on top\u2010down solvent exchange. The densely porous and smooth bottom\u2010surface of JPVA hydrogel minimizes adhesion of fibroblasts and does not trigger any visceral adhesion, and its loose extracellular\u2010matrix\u2010like porous and rough top\u2010surface can significantly improve fibroblast adhesion and tissue growth, leading to superior abdominal wall defect treatment to commercially available PP and PCO meshes. With unique anti\u2010swelling property (maximum swelling ratio: 6.4%), JPVA hydrogel has long\u2010lasting anti\u2010deformation performance and maintains high mechanical strength after immersion in phosphate\u2010buffered saline (PBS) for 14 days, enabling tolerance to the maximum abdominal pressure in an internal wet environment. By integrating visceral anti\u2010adhesion and defect pro\u2010healing with anti\u2010deformation, the JPVA hydrogel patch shows great prospects for efficient internal soft\u2010tissue defect repair.<\/jats:p>","DOI":"10.1002\/adma.202108992","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T07:38:57Z","timestamp":1641281937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":213,"title":["Peritoneum\u2010Inspired Janus Porous Hydrogel with Anti\u2010Deformation, Anti\u2010Adhesion, and Pro\u2010Healing Characteristics for Abdominal Wall Defect Treatment"],"prefix":"10.1002","volume":"34","author":[{"given":"Weiwen","family":"Liang","sequence":"first","affiliation":[{"name":"Guangdong Institute of Gastroenterology Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 510655 P. R. 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