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Here, by loading a chemotherapeutic drug methotrexate (MTX) in hollow manganese dioxide (MnO<jats:sub>2<\/jats:sub>) nanoparticles with surface modification of the Opca protein of <jats:italic>Neisseria meningitidis<\/jats:italic>, a bionic nanotherapeutic system (MTX@MnO<jats:sub>2<\/jats:sub>\u2010Opca) is demonstrated to effectively overcome the BBB. The presence of the Opca protein enables the drug to cross the BBB and penetrate into tumor tissues. After accumulating in glioblastoma, the nanotherapeutic system catalyzes the decomposition of excess H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in the tumor tissue and thereby generates O<jats:sub>2<\/jats:sub>, which alleviates tumor hypoxia and enhances the effect of chemotherapy in the treatment of glioblastoma. This bionic nanotherapeutic system may exhibit great potential in the treatment of glioblastoma.<\/jats:p>","DOI":"10.1002\/adma.202109213","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T12:47:47Z","timestamp":1641559667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["<i>Neisseria meningitidis<\/i> Opca Protein\/MnO<sub>2<\/sub> Hybrid Nanoparticles for Overcoming the Blood\u2013Brain Barrier to Treat Glioblastoma"],"prefix":"10.1002","volume":"34","author":[{"given":"Cheng\u2010Yuan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery West China Hospital Sichuan University  Chengdu 610041 P. R. 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