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The development of hydrogel\u2010based 4D bioinks, especially those allowing living cell printing, with easy preparation, defined composition, and controlled physical properties is critically important for 4D bioprinting. Here, a single\u2010component jammed micro\u2010flake hydrogel (MFH) system with heterogeneous size distribution, which differs from the conventional granular microgel, has been developed as a new cell\u2010laden bioink for 4D\u00a0bioprinting. This jammed cytocompatible MFH features scalable production and straightforward composition with shear\u2010thinning, shear\u2010yielding, and rapid self\u2010healing properties. As such, it can be smoothly printed into stable 3D\u00a0bioconstructs, which can be further cross\u2010linked to form a gradient in cross\u2010linking density when a photoinitiator and a UV absorber are incorporated. After being subject to shape morphing, a variety of complex bioconstructs with well\u2010defined configurations and high cell viability are obtained. Based on this system, 4D\u00a0cartilage\u2010like tissue formation is demonstrated as a\u00a0proof\u2010of\u2010concept. The establishment of this versatile new 4D bioink system may open up a\u00a0number of applications in tissue engineering.<\/jats:p>","DOI":"10.1002\/adma.202109394","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T14:49:55Z","timestamp":1642862995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Jammed Micro\u2010Flake Hydrogel for Four\u2010Dimensional Living Cell Bioprinting"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-7098","authenticated-orcid":false,"given":"Aixiang","family":"Ding","sequence":"first","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oju","family":"Jeon","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaelyn L.","family":"Gasvoda","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick","family":"Wells","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-4625","authenticated-orcid":false,"given":"Eben","family":"Alsberg","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Biomedical Engineering University of Illinois at Chicago  Chicago IL 60612 USA"},{"name":"Departments of Mechanical &amp; Industrial Engineering Orthopaedics and Pharmacology University of Illinois at Chicago  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"116","volume":"84","author":"Tibbits S.","year":"2014","journal-title":"Archit. 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