{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:08:46Z","timestamp":1791288526124,"version":"4.3.0"},"reference-count":54,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["20ZR1442100"],"award-info":[{"award-number":["20ZR1442100"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The harsh urine microenvironment (UME), as an inherent hurdle, endangers and renders urethral repair unreachable. Innovatively, the unfavorable UME is utilized as the design source to construct a UME\u2010responsive 3D\u2010printed hydrogel patch for realizing scarless memory repair, wherein laser\u2010excited reactive oxygen species (ROS) production and mechanical strength elevation using chemically crosslinked silicon quantum dots are accessible. Intriguingly, the proposed composite scaffolds can respond to Ca\n                    <jats:sup>2+<\/jats:sup>\n                    in urine, cause structure reconfiguration, and repress swelling to further enhance scaffold stiffness. Systematic experiments validate that ROS birth and unexpected stiffness elevation in such UME\u2010responsive scaffolds can realize scarless memory repair of the urethra in vivo. Comprehensive mechanism explorations uncover that the activations of cell proliferation and collagen\u2010related genes (e.g., MMP\u20101 and COL3A1) and the dampening of fibrosis\u2010related (e.g., TGF\u2010\u03b2\/Smad) and mechanosensitive genes (e.g., YAP\/TAZ) are responsible for the scarless memory repair of such UME\u2010responsive scaffolds via enhancing collagen deposition, recalling mechanical memory, decreasing fibrosis and inflammation, and accelerating angiogenesis. The design rationales (e.g., UME\u2010initiated structure reconfiguration and antiswelling) can serve as an instructive and general approach for urethra repair.\n                  <\/jats:p>","DOI":"10.1002\/adma.202109522","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T09:52:49Z","timestamp":1643968369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Urine\u2010Microenvironment\u2010Initiated Composite Hydrogel Patch Reconfiguration Propels Scarless Memory Repair and Reinvigoration of the Urethra"],"prefix":"10.1002","volume":"34","author":[{"given":"Ming","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University  No. 600 Yi\u2010Shan Road Shanghai 200233 P. R. China"},{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"},{"name":"Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue Engineering Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University  No. 600 Yi\u2010Shan Road Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University  No. 600 Yi\u2010Shan Road Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoting","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-1164","authenticated-orcid":false,"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound and Central Laboratory Nanotechnology and Intestinal Microecology Research Center Shanghai Tenth People's Hospital Tongji University School of Medicine  No. 301 Yan\u2010chang\u2010zhong Road Shanghai 200072 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University  No. 600 Yi\u2010Shan Road Shanghai 200233 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000637"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.02.014"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000921"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.12.008"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.1177\/0885328219882638"},{"key":"e_1_2_9_2_4","doi-asserted-by":"publisher","DOI":"10.1002\/polb.22259"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29356"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2021.33.4.309"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2018.0350"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ib00149g"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00830-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010626"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007429"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.201600042"},{"key":"e_1_2_9_6_4","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900099"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13115-3"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26236-5"},{"key":"e_1_2_9_7_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.04.024"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201900372"},{"key":"e_1_2_9_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106317"},{"key":"e_1_2_9_8_4","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00897-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-271304"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-286872"},{"key":"e_1_2_9_10_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.09.056"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-019-0198-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.773085"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.48"},{"key":"e_1_2_9_12_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba2374"},{"key":"e_1_2_9_12_4","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb3312"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.03.074"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b00683"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202006697"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2812"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201800504"},{"key":"e_1_2_9_16_3","doi-asserted-by":"publisher","DOI":"10.1177\/0885328220907784"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800021"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201905124"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(07)57004-X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.03.032"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.11.040"},{"key":"e_1_2_9_19_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110287"},{"key":"e_1_2_9_19_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.03.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5482.1202"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1160.h81602001160_1160_1167"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2151"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4780"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240104"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101065"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101305"},{"key":"e_1_2_9_25_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.101009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.12.016"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202109522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.202109522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202109522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:15:43Z","timestamp":1759770943000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202109522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,27]]},"references-count":54,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/adma.202109522"],"URL":"https:\/\/doi.org\/10.1002\/adma.202109522","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,27]]},"assertion":[{"value":"2021-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2109522"}}