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To enhance the corneal permeability of RF and promote its efficacy in the treatment of keratoconus, novel hibiscus\u2010like RF@ZIF\u20108 microsphere composites [6RF@ZIF\u20108 NF (nanoflake)] are prepared using ZIF\u20108 nanomaterials as carriers, which are characterized by their hydrophobicity, positive potential, biocompatibility, high loading capacities, and large surface areas. Both hematoxylin and eosin endothelial staining and TUNEL assays demonstrate excellent biocompatibility of 6RF@ZIF\u20108 NF. In in vivo studies, the 6RF@ZIF\u20108 NF displayed excellent corneal permeation, and outstanding transepithelial CXL (TE\u2010CXL) efficacy, slightly better than the conventional CXL protocol. Furthermore, the special hibiscus\u2010like structures of 6RF@ZIF\u20108 NF meant that it has better TE\u2010CXL efficacy than that of 6RF@ZIF\u20108 NP (nanoparticles) due to the larger contact area with the epithelium and the shorter RF release passage. These results suggest that the 6RF@ZIF\u20108 NF are promising for transepithelial corneal cross\u2010linking, avoiding the need for epithelial debridement.<\/jats:p>","DOI":"10.1002\/adma.202109865","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T16:54:46Z","timestamp":1647968086000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Engineering Hibiscus\u2010Like Riboflavin\/ZIF\u20108 Microsphere Composites to Enhance Transepithelial Corneal Cross\u2010Linking"],"prefix":"10.1002","volume":"34","author":[{"given":"Mei","family":"Yang","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology Eye and ENT Hospital Fudan University Key Laboratory of Myopia Chinese Academy of Medical Sciences  Shanghai 200030 China"},{"name":"Shanghai Research Center of Ophthalmology and Optometry  Shanghai 200030 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