{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:56:03Z","timestamp":1792205763616,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21625503"],"award-info":[{"award-number":["21625503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104031"],"award-info":[{"award-number":["22104031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for glioblastoma (GBM). However, the blood\u2212brain barrier (BBB) and hypoxic microenvironment greatly limit the SDT efficiency. In this work, a biodegradable nanoplatform (termed as CSI) is fabricated by encapsulating catalase (CAT) into silica nanoparticles (CAT@SiO\n                    <jats:sub>2<\/jats:sub>\n                    ) for tumor hypoxia relief, and then loaded with the sonosensitizer indocyanine green (ICG). Inspired by the ability of macrophages to cross the BBB, CSI is further coated with AS1411 aptamer\u2010modified macrophage exosomes to form CSI@Ex\u2010A, which possesses efficient BBB penetration and good cancer\u2010cell\u2010targeting capability. After tumor cell endocytosis, highly expressed glutathione (GSH) triggeres biodegradation of the nanoplatform and the released CAT catalyzes hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) to produce O\n                    <jats:sub>2<\/jats:sub>\n                    to relieve tumor hypoxia. The GSH depletion and O\n                    <jats:sub>2<\/jats:sub>\n                    self\u2010supplying effectively enhances the SDT efficiency both in vitro and in vivo. In addition, the resulting CSI@Ex\u2010A exhibits good biocompatibility and long circulation time. These findings demonstrate that CSI@Ex\u2010A may serve as a competent nanoplatform for GBM therapy, with potential for clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202110364","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T06:59:08Z","timestamp":1644303548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":312,"title":["Engineering Macrophage Exosome Disguised Biodegradable Nanoplatform for Enhanced Sonodynamic Therapy of Glioblastoma"],"prefix":"10.1002","volume":"34","author":[{"given":"Tingting","family":"Wu","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University  Wuhan 430062 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University  Wuhan 430062 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-4556","authenticated-orcid":false,"given":"Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University  Wuhan 430062 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University  Wuhan 430062 P. R. 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