{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:57:10Z","timestamp":1792637830561,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0105900"],"award-info":[{"award-number":["2017YFA0105900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A unique robotic medical platform is designed by utilizing cell robots as the active \u201cTrojan horse\u201d of oncolytic adenovirus (OA), capable of tumor\u2010selective binding and killing. The OA\u2010loaded cell robots are fabricated by entirely modifying OA\u2010infected 293T cells with cyclic arginine\u2013glycine\u2013aspartic acid tripeptide (cRGD) to specifically bind with bladder cancer cells, followed by asymmetric immobilization of Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles (NPs) on the cell surface. OA can replicate in host cells and induce cytolysis to release the virus progeny to the surrounding tumor sites for sustainable infection and oncolysis. The asymmetric coating of magnetic NPs bestows the cell robots with effective movement in various media and wireless manipulation with directional migration in a microfluidic device and bladder mold under magnetic control, further enabling steerable movement and prolonged retention of cell robots in the mouse bladder. The biorecognition of cRGD and robust, controllable propulsion of cell robots work synergistically to greatly enhance their tissue penetration and anticancer efficacy in the 3D cancer spheroid and orthotopic mouse bladder tumor model. Overall, this study integrates cell\u2010based microrobots with virotherapy to generate an attractive robotic system with tumor specificity, expanding the operation scope of cell robots in biomedical community.\n                  <\/jats:p>","DOI":"10.1002\/adma.202201042","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T15:44:00Z","timestamp":1650642240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Magnetic\u2010Powered Janus Cell Robots Loaded with Oncolytic Adenovirus for Active and Targeted Virotherapy of Bladder Cancer"],"prefix":"10.1002","volume":"34","author":[{"given":"Zhaoqing","family":"Cong","sequence":"first","affiliation":[{"name":"Institute of Urology The Third Affiliated Hospital of Shenzhen University  Shenzhen 518000 P. R. China"},{"name":"Shenzhen Following Precision Medical Research Institute Luohu Hospital Group  Shenzhen 518000 P. R. 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