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Artificial exoskeletons have, to date, provided physicochemical shelters to the cells inside in the first stage of technological development, and further advances in the field demand catalytically empowered, cellular hybrid systems that augment the biological functions of cells and even introduce completely new functions to the cells. This work describes a facile and generalizable strategy for empowering living cells with extrinsic catalytic capability through nanoencapsulation of living cells with a supramolecular metal\u2013organic complex of Fe<jats:sup>3+<\/jats:sup> and benzene\u20101,3,5\u2010tricarboxylic acid (BTC). A series of enzymes are embedded in situ, without loss of catalytic activity, in the Fe<jats:sup>3+<\/jats:sup>\u2010BTC shells, not to mention the superior characteristics of cytocompatible and rapid shell\u2010forming processes. The nanoshell enhances the catalytic efficiency of multienzymatic cascade reactions by confining reaction intermediates to its internal voids and the nanoencapsulated cells acquire exogenous biochemical functions, including enzymatic cleavage of lethal octyl\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranoside into <jats:sc>d<\/jats:sc>\u2010glucose, with autonomous cytoprotection. The system will provide a versatile, nanoarchitectonic tool for interfacing biological cells with functional materials, especially for catalytic bioempowerment of living cells.<\/jats:p>","DOI":"10.1002\/adma.202201247","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T23:16:07Z","timestamp":1654038967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Cell\u2010in\u2010Catalytic\u2010Shell Nanoarchitectonics: Catalytic Empowerment of Individual Living Cells by Single\u2010Cell Nanoencapsulation"],"prefix":"10.1002","volume":"34","author":[{"given":"Hojae","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Cell\u2010Encapsulation Research Department of Chemistry KAIST  Daejeon 34141 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohyouck","family":"Park","sequence":"additional","affiliation":[{"name":"Center for 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