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Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows promising potential for GBM therapy in clinical trials. However, significant challenges include limited blood\u2013brain\u2010barrier (BBB) penetration, poor targeting of GBM tissue\/cells, and systemic side effects, which hinder its efficacy in GBM therapy. To surmount these challenges,\u00a0new GBM\u2010cell membrane camouflaged and pH\u2010sensitive biomimetic nanoparticles (MNPs) inspired by the fact that cancer cells readily pass the BBB and localize with homologous cells, are developed. This study's results show that MNPs can efficiently co\u2010load TMZ and CDDP, transport these across the BBB to specifically target GBM. Incorporation of pH\u2010sensitive polymer then allows for controlled release of drug cargos at GBM sites for combination drug therapy. Mice bearing orthotopic U87MG or drug\u2010resistant U251\n                    <jats:sup>R<\/jats:sup>\n                    GBM tumor and treated with MNPs@TMZ+CDDP show a potent anti\u2010GBM effect, greatly extending the survival time relative to mice receiving single\u2010drug loaded nanoparticles. No obvious side effects are apparent in histological analyses or blood routine studies. Considering these results, the study's new nanoparticle formulation overcomes multiple challenges currently limiting the efficacy of combined TMZ and CDDP GBM drug therapy and appears to be a promising strategy for future GBM combinatorial chemotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202203958","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T19:04:21Z","timestamp":1656011061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":194,"title":["Brain Co\u2010Delivery of Temozolomide and Cisplatin for Combinatorial Glioblastoma Chemotherapy"],"prefix":"10.1002","volume":"34","author":[{"given":"Yan","family":"Zou","sequence":"first","affiliation":[{"name":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"},{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences &amp; School of Pharmacy Henan University  Kaifeng Henan 475004 China"},{"name":"Centre for Motor Neuron Disease Research Macquarie Medical School Faculty of Medicine Health and Human Sciences Macquarie University  Sydney NSW 2109 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"},{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences &amp; School of Pharmacy Henan University  Kaifeng Henan 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"},{"name":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences &amp; 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