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In particular, in recent years, our\u00a0group has focused on developing sperm\u2010microcarriers to assist sperm cells with motion deficiencies or low sperm count (two of the most prominent male infertility problems) to reach the oocyte toward in\u2010vivo\u2010assisted fertilization. Different sperm carriers, considering their motion in realistic media and confined environments, have been optimized. However, the already\u2010reported sperm carriers have been mainly designed to transport single sperm cell, with limited functionality. Thus, to take a step forward, here, the development of a 4D\u2010printed multifunctional microcarrier containing soft and smart materials is reported. These microcarriers can not only transport and deliver multiple motile sperm cells, but also release heparin and mediate local enzymatic reactions by hyaluronidase\u2010loaded polymersomes (HYAL\u2010Psomes). 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