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Currently, no effective drugs can be clinically applied to prevent the development of AAA. Herein, a \u201cone stone for multiple birds\u201d strategy for AAA therapy is reported. As a proof of concept, three bioactive conjugates are designed and synthesized, which can assemble into nanomicelles. Cellularly, these nanomicelles significantly inhibit migration and activation of inflammatory cells as well as protect vascular smooth muscle cells (VSMCs) from induced oxidative stress, calcification and apoptosis, with the best effect for nanomicelles (TPTN) derived from a conjugate defined as TPT. After intravenous delivery, TPTN efficiently accumulates in the aneurysmal tissue of AAA rats, showing notable distribution in neutrophils, macrophages and VSMCs, all relevant to AAA pathogenesis. Whereas three examined nanomicelles effectively delay expansion of AAA in rats, TPTN most potently prevents AAA growth by simultaneously normalizing the pro\u2010inflammatory microenvironment and regulating multiple pathological cells. TPTN is effective even at 0.2\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>. Besides, TPTN can function as a bioactive nanoplatform for site\u2010specifically delivering and triggerably releasing anti\u2010aneurysmal drugs, affording synergistic therapeutic effects. Consequently, TPTN is a promising multi\u2010bioactive nanotherapy and bioresponsive targeting delivery nanocarrier for effective therapy of AAA and other inflammatory vascular diseases.<\/jats:p>","DOI":"10.1002\/adma.202204455","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T23:44:23Z","timestamp":1662767063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Multi\u2010Bioactive Nanomicelle\u2010Based \u201cOne Stone for Multiple Birds\u201d Strategy for Precision Therapy of Abdominal Aortic Aneurysms"],"prefix":"10.1002","volume":"34","author":[{"given":"Wenjie","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics College of Pharmacy Third Military Medical University (Army Medical University)  Chongqing 400038 China"},{"name":"Department of Vascular Surgery Renmin Hospital of Wuhan University Wuhan University  Wuhan 430060 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