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However, lipids can also regulate immune activity and their presence may also contribute to biomaterial\u2010induced foreign body responses (FBR) and fibrosis. Here it is demonstrated that the surface presentation of lipids on implant affects FBR by influencing reactions of immune cells to materials as well as their resultant inflammatory\/suppressive polarization. Time\u2010of\u2010flight secondary ion mass spectroscopy (ToF\u2010SIMS) is employed to characterize lipid deposition on implants that are surface\u2010modified chemically with immunomodulatory small molecules. Multiple immunosuppressive phospholipids (phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine, and sphingomyelin) are all found to deposit preferentially on implants with anti\u2010FBR surface modifications in mice. Significantly, a set of 11 fatty acids is enriched on unmodified implanted devices that failed in both mice and humans, highlighting relevance across species. Phospholipid deposition is also found to upregulate the transcription of anti\u2010inflammatory genes in murine macrophages, while fatty acid deposition stimulated the expression of pro\u2010inflammatory genes. These results provide further insights into how to improve the design of biomaterials and medical devices to mitigate biomaterial material\u2010induced FBR and fibrosis.<\/jats:p>","DOI":"10.1002\/adma.202205709","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T06:59:20Z","timestamp":1677999560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lipid Deposition Profiles Influence Foreign Body Responses"],"prefix":"10.1002","volume":"35","author":[{"given":"Christian C.","family":"Schreib","sequence":"first","affiliation":[{"name":"Department of Bioengineering Rice University  6500 Main Street Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  6500 Main Street Houston TX 77030 USA"},{"name":"Lonza Inc.\u00a0  14905 Kirby 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