{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:49:23Z","timestamp":1790876963295,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014189","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["421020\u201003"],"award-info":[{"award-number":["421020\u201003"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CAP22011\u2010000"],"award-info":[{"award-number":["CAP22011\u2010000"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The sense of spiciness is related to the stimulation of vanilloid compounds contained in the foods. Although, the spiciness is commonly considered as the part of taste, it is more classified to the sense of pain stimulated on a tongue, namely, pungency, which is described as a tingling or burning on the tongue. Herein, first, a reusable electronic tongue based on a transient receptor potential vanilloid 1 (TRPV1) nanodisc conjugated graphene field\u2010effect transistor is fabricated and spiciness\u2010related pain evaluation with reusable electrode is demonstrated. The pungent compound reactive receptor TRPV1 is synthesized in the form of nanodiscs to maintain stability and reusability. The newly developed platform shows highly selective and sensitive performance toward each spiciness related vanilloid compound repeatably: 1 aM capsaicin, 10 aM dihydrocapsaicin, 1 fM piperine, 10\u00a0nM allicin, and 1 pM AITC. The binding mechanism is also examined by simulation. Furthermore, the elimination of the burning sensation on the tongue after eating spicy foods is not investigated. Based on the synthesis of micelles composed of casein protein (which is contained in skim milk) that remove pungent compounds bound to TRPV1 nanodisc, the deactivation of TRPV1 is investigated, and the electrode is reusable that mimics electronic tongue.<\/jats:p>","DOI":"10.1002\/adma.202206198","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T04:57:33Z","timestamp":1677646653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Reusable Electronic Tongue Based on Transient Receptor Potential Vanilloid 1 Nanodisc\u2010Conjugated Graphene Field\u2010Effect Transistor for a Spiciness\u2010Related Pain Evaluation"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-9309","authenticated-orcid":false,"given":"Sung Eun","family":"Seo","sequence":"first","affiliation":[{"name":"Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South Korea"},{"name":"Department of Nano Engineering SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University (SKKU)  2066 Seobu\u2010ro, Jangan\u2010gu Suwon 16419 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-4602","authenticated-orcid":false,"given":"Seong Gi","family":"Lim","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South Korea"},{"name":"Department of Nano Engineering SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University (SKKU)  2066 Seobu\u2010ro, Jangan\u2010gu Suwon 16419 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3587-0877","authenticated-orcid":false,"given":"Kyung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South Korea"},{"name":"Department of Nano Engineering SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University (SKKU)  2066 Seobu\u2010ro, Jangan\u2010gu Suwon 16419 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Jae","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Nano Engineering SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University (SKKU)  2066 Seobu\u2010ro, Jangan\u2010gu Suwon 16419 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomin","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Kim","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bionano Engineering Center for Bionano Intelligence Education and Research Hanyang University  55 Hanyangdaehak\u2010ro, Sangnok\u2010gu Ansan 15588 South\u00a0Korea"},{"name":"Department of Chemical and Biological Engineering Hanbat National University  125 Dongseo\u2010daero, Yuseong\u2010gu Daejeon 34158 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Yee","family":"Jang","sequence":"additional","affiliation":[{"name":"Core Research Facility &amp; Analysis Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  125 Gwahak\u2010ro, Yuseong\u2010gu Daejeon 34141 South\u00a0Korea"},{"name":"School of Pharmacy University of Maryland Eastern Shore  Princess Anne MD 21853 United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Woo","family":"Oh","sequence":"additional","affiliation":[{"name":"Core Research Facility &amp; Analysis Center Korea Research Institute of Bioscience and Biotechnology (KRIBB)  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South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung G.","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for NanoBio Development National NanoFab Center  291 Daehak\u2010ro, Yuseong\u2010gu Daejeon 34141 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering Hanbat National University  125 Dongseo\u2010daero, Yuseong\u2010gu Daejeon 34158 South\u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyoung","family":"Ha","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Maryland Eastern Shore  Princess Anne MD 21853 United\u00a0States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5936-244X","authenticated-orcid":false,"given":"Oh 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