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These dynamics and fibrous nanostructures are imperative in obtaining the correct cell\/material interactions. Consequently, the challenge to engineer functional dynamics in a fibrous hydrogel and recapitulate native ECM properties remains a bottle\u2010neck to biomimetic hydrogel environments. Here,\u00a0the molecular tuning of a supramolecular benzene\u20101,3,5\u2010tricarboxamide (BTA) hydrogelator via simple modulation of hydrophobic substituents is reported. This tuning results in fibrous hydrogels with accessible viscoelasticity over 5 orders of magnitude, while maintaining a constant equilibrium storage modulus. BTA hydrogelators are created with systematic variations in the number of\u00a0hydrophobic carbon atoms, and this is observed to control the viscoelasticity and stress\u2010relaxation timescales in a logarithmic fashion. Some of these\u00a0BTA hydrogels are shear\u2010thinning, self\u2010healing, extrudable, and injectable, and can be 3D printed into multiple layers. These hydrogels show high cell viability for chondrocytes and human mesenchymal stem cells, establishing their use in tissue engineering applications. This simple molecular tuning by changing hydrophobicity (with just a few carbon atoms) provides precise control over the viscoelasticity and 3D printability in fibrillar hydrogels and can be ported onto other 1D self\u2010assembling structures. The molecular control and design of hydrogel network dynamics can push the field of supramolecular chemistry toward\u00a0the design of new ECM\u2010mimicking hydrogelators for numerous cell\u2010culture and tissue\u2010engineering applications and give access toward\u00a0highly biomimetic bioinks for bioprinting.<\/jats:p>","DOI":"10.1002\/adma.202207053","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T18:25:00Z","timestamp":1677695100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Molecular Tuning of a Benzene\u20101,3,5\u2010Tricarboxamide Supramolecular Fibrous Hydrogel Enables Control over Viscoelasticity and Creates Tunable ECM\u2010Mimetic Hydrogels and Bioinks"],"prefix":"10.1002","volume":"35","author":[{"given":"Shahzad","family":"Hafeez","sequence":"first","affiliation":[{"name":"Department of Complex Tissue Regeneration MERLN Institute for Technology\u2010Inspired Regenerative Medicine Maastricht University  P.O. Box 616 Maastricht 6200 MD The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana A.","family":"Aldana","sequence":"additional","affiliation":[{"name":"Department of Complex Tissue Regeneration MERLN Institute for Technology\u2010Inspired Regenerative Medicine Maastricht University  P.O. Box 616 Maastricht 6200 MD The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Duimel","sequence":"additional","affiliation":[{"name":"Maastricht MultiModal Molecular Imaging (M4I) Institute Maastricht University  P.O. Box 616 Maastricht 6200 MD The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floor A. A.","family":"Ruiter","sequence":"additional","affiliation":[{"name":"Department of Complex Tissue Regeneration MERLN Institute for Technology\u2010Inspired Regenerative Medicine Maastricht University  P.O. Box 616 Maastricht 6200 MD The Netherlands"},{"name":"Department of Cell Biology\u2010Inspired Tissue Engineering MERLN Institute for Technology\u2010Inspired Regenerative Medicine Maastricht University  P.O. Box 616 Maastricht 6200 MD The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monize Caiado","family":"Decarli","sequence":"additional","affiliation":[{"name":"Department of Complex Tissue Regeneration MERLN Institute for Technology\u2010Inspired Regenerative Medicine Maastricht University  P.O. Box 616 Maastricht 6200 MD The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Lapointe","sequence":"additional","affiliation":[{"name":"Department of Cell Biology\u2010Inspired Tissue Engineering MERLN Institute for Technology\u2010Inspired Regenerative Medicine Maastricht University  P.O. 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