{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:54:55Z","timestamp":1789541695332,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["AFOSR FA2386\u201020\u20101\u20104060"],"award-info":[{"award-number":["AFOSR FA2386\u201020\u20101\u20104060"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prompt on\u2010site diagnosis of SARS\u2010CoV\u20102 with other respiratory infections will have minimized the global impact of the COVID\u201019 pandemic through rapid, effective management. However, no such multiplex point\u2010of\u2010care (POC) chip has satisfied a suitable sensitivity of gold\u2010standard nucleic acid amplification tests (NAATs). Here, a rapid multiplexed ultrasensitive sample\u2010to\u2010answer loop\u2010mediated isothermal amplification (MUSAL) chip operated by simple LED\u2010driven photothermal amplification to detect six targets from single\u2010swab sampling is presented. First, the MUSAL chip allows ultrafast on\u2010chip sample preparation with \u2248500\u2010fold preconcentration at a rate of 1.2\u00a0mL min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Second, the chip enables contamination\u2010free amplification using autonomous target elution into on\u2010chip reagents by photothermal activation. Finally, the chip accomplishes multiplexed on\u2010chip diagnostics of SARS\u2010CoV\u20102 and influenza viruses with a limit of detection (LoD) of 0.5 copies \u00b5L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . The rapid, ultrasensitive, cost\u2010effective sample\u2010to\u2010answer chip with a multiplex capability will allow timely management of various pandemics situations that may be faced shortly.\n                  <\/jats:p>","DOI":"10.1002\/adma.202207138","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T02:54:09Z","timestamp":1668740049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Multiplexed Ultrasensitive Sample\u2010to\u2010Answer RT\u2010LAMP Chip for the Identification of SARS\u2010CoV\u20102 and Influenza Viruses"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0149-8694","authenticated-orcid":false,"given":"Minsun","family":"Song","sequence":"first","affiliation":[{"name":"Harvard Medical School Harvard University  Boston MA 02115 USA"},{"name":"Division of Engineering in Medicine and Renal Division Department of Medicine Brigham Women's Hospital  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SoonGweon","family":"Hong","sequence":"additional","affiliation":[{"name":"Harvard Medical School Harvard University  Boston MA 02115 USA"},{"name":"Division of Engineering in Medicine and Renal Division Department of Medicine Brigham Women's Hospital  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1436-4054","authenticated-orcid":false,"given":"Luke P.","family":"Lee","sequence":"additional","affiliation":[{"name":"Harvard Medical School Harvard University  Boston MA 02115 USA"},{"name":"Division of Engineering in Medicine and Renal Division Department of Medicine Brigham Women's Hospital  Boston MA 02115 USA"},{"name":"Department of Bioengineering Department of Electrical Engineering and Computer Science University of California at Berkeley  Berkeley CA 94720 USA"},{"name":"Department of Biophysics Institute of Quantum Biophysics Sungkyunkwan University (SKKU)  Suwon Gyeonggi\u2010do 16419 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"World Health Organization https:\/\/covid19.who.int\/(accessed: August2022)."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65534"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200282"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization Clinical management of COVID\u201019: interim guidance https:\/\/apps.who.int\/iris\/handle\/10665\/332196(accessed: May2020)."},{"key":"e_1_2_9_5_1","first-page":"534","volume":"28","author":"Curtolo A.","year":"2020","journal-title":"Infez. 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