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However, therapies targeting a singular metabolic pathway are always counteracted by the metabolic reprogramming of cancer, resulting in unsatisfactory therapeutic effect. Herein, this work employs poly(ethylene glycol)\u2010coated (PEGylated) liposomes as the drug delivery system for both mannose and levamisole hydrochloride to simultaneously inhibit glycolysis and restrain mitochondrial energy metabolism and thus inhibit tumor growth. In combination with radiotherapy, the liposomes can not only modulate the immunosuppressive TME by cellular metabolism regulation to achieve potent therapeutic effect for local tumors, but also suppress the M2 macrophage proliferation triggered by X\u2010ray irradiation and thus enhance the immune response to inhibit metastatic lesions. In brief, this work provides a new therapeutic strategy targeting the special metabolic traits of cancer cells and immunosuppressive TAMs to enhance the abscopal effect of radiotherapy for cancer.<\/jats:p>","DOI":"10.1002\/adma.202207343","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T07:38:20Z","timestamp":1665560300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Metabolic Homeostasis\u2010Regulated Nanoparticles for Antibody\u2010Independent Cancer Radio\u2010Immunotherapy"],"prefix":"10.1002","volume":"34","author":[{"given":"Wenhao","family":"Shen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; 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