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These evolutionary optimized substances provide highest efficiencies, e.g., in harvesting solar energy or providing extreme stability, and are intrinsically biocompatible. However, the mimicry of biological materials is limited to a few successful applications since there is still a lack of the tools to recreate natural materials. Herein, such means are provided based on a peptide library derived from the silaffin protein R5 that enables rational biomimetic materials design. It is now evident that biomaterials do not form via mechanisms observed in vitro. Instead, the material's function and morphology are predetermined by precursors that self\u2010assemble in solution, often from a combination of protein and salts. These assemblies act as templates for biomaterials. The RRIL peptides used here are a small part of the silica\u2010precipitation machinery in diatoms. By connecting RRIL motifs via varying central bi\u2010 or trifunctional residues, a library of stereoisomers is generated, which allows characterization of different template structures in the presence of phosphate ions by combining residue\u2010resolved real\u2010time NMR spectroscopy and molecular dynamics (MD) simulations. Understanding these templates in atomistic detail, the morphology of silica particles is controlled via manipulation of the template precursors.<\/jats:p>","DOI":"10.1002\/adma.202207586","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T23:05:19Z","timestamp":1670886319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Understanding Self\u2010Assembly of Silica\u2010Precipitating Peptides to Control Silica Particle Morphology"],"prefix":"10.1002","volume":"35","author":[{"given":"Johannes","family":"Strobl","sequence":"first","affiliation":[{"name":"Institute of Biological Chemistry Faculty of Chemistry University of Vienna  W\u00e4hringer Str. 38 Vienna 109 Austria"},{"name":"Vienna Doctoral School in Chemistry (DoSChem) University of Vienna  W\u00e4hringer Str. 42 Vienna 1090 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