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In\u00a0this\u00a0work, inspired by pollen in nature, novel shell\u2013core aerosol particles (APs) capable of Brownian motion are constructed for respiratory delivery. Drugs\u2010loaded poly(lactic\u2010<jats:italic>co<\/jats:italic>\u2010glycolic acid) nanoparticles are prepared by emulsification to form the inner core, and the membranes of macrophages are extracted to form the outer shell. The optimized size and the shell\u2013core structure endow APs with Brownian motion and atomization stability, thus enabling the APs to reach the bronchi and alveoli deeply for effective deposition. Camouflaging the\u00a0macrophage membranes equips the APs with immune evasion. In vitro experiments prove that deferoxamine (DFO)\u2010loaded APs (DFO@APs) can promote the angiogenesis of human umbilical vein endothelial cells. A hyperoxia\u2010induced bronchopulmonary dysplasia (BPD) model is constructed to validate the efficiency of DFO@APs. In BPD mice, DFO@APs can release DFO in the alveolar interstitium, thus promoting the reconstruction of microvasculature, ultimately inducing lung development for treating BPD. In conclusion, this study develops \u201cpollen\u201d\u2010inspired shell\u2013core aerosol particles capable of Brownian motion, which provides a novel idea and theoretical basis for respiratory administration.<\/jats:p>","DOI":"10.1002\/adma.202207744","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T16:30:11Z","timestamp":1673368211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pollen\u2010Inspired Shell\u2013Core Aerosol Particles Capable of Brownian Motion for Pulmonary Vascularization"],"prefix":"10.1002","volume":"35","author":[{"given":"Yanru","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neonatology Xinhua Hospital Shanghai Jiaotong University School of Medicine  1665 Kongjiang Road Shanghai 200082 P. R. 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