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Iron is essential for bacterial growth and metabolism, and bacteria can thus accumulate iron from surrounding cells to maintain biofilm formation and survival. Consequently, iron deficiency in the biofilm microenvironment (BME) leads to the functional failure of innate immune cells. Herein, a novel antibiofilm strategy of iron\u2010actuated Janus ion therapy (IJIT) is proposed to regulate iron metabolism in both bacterial biofilm and immune cells. A BME\u2010responsive photothermal microneedle patch (FGO@MN) is synthesized by the growth of Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \u00a0nanoparticles on graphene oxide nanosheets and then encapsulated in methacrylated hyaluronic acid needle tips. The catalytic product of \u00b7OH by FGO@MN in BME disrupts the bacterial heat\u2010shock proteins, coercing biofilm thermal sensitization. As synergistic mild photothermal treatment triggers iron uptake, the intracellular iron overload further induces ferroptosis\u2010like death. Moreover, iron\u2010nourished neutrophils around BME can be rejuvenated for reactivating the suppressed antibiofilm function. Thus, more than 95% BBIs elimination can be achieved by combining heat stress\u2010triggered iron interference with iron\u2010nutrient immune reactivation. Furthermore, in vivo experiments validate the scavenging of refractory BBI after 15\u00a0days, suggesting the promising perspective of IJIT in future clinical application.\n                  <\/jats:p>","DOI":"10.1002\/adma.202207961","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T06:24:45Z","timestamp":1665728685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":249,"title":["Photothermal Nanozyme\u2010Based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron\u2010Actuated Janus Ion Therapy"],"prefix":"10.1002","volume":"34","author":[{"given":"Wanbo","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei Anhui 230001 P. R. 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