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In addition to their ultrahigh catalytic activities, their inherent and unique charge\u2010carrier\u2010releasing properties can be used to initiate various redox catalytic reactions, displaying bright prospects for future medical applications. Triggered by mechanical energy, piezocatalytic materials can release electrons\/holes, catalyze redox reactions of substrates, or intervene in biological processes to promote the production of effector molecules for medical purposes, such as decontamination, sterilization, and therapy. Such a medical application of piezocatalysis is termed as piezocatalytic medicine (PCM) herein. To pioneer novel medical technologies, especially therapeutic modalities, this review provides an overview of the state\u2010of\u2010the\u2010art research progress in piezocatalytic medicine. First, the principle of piezocatalysis and the preparation methodologies of piezoelectric materials are introduced. Then, a comprehensive summary of the medical applications of piezocatalytic materials in tumor treatment, antisepsis, organic degradation, tissue repair and regeneration, and biosensing is provided. Finally, the main challenges and future perspectives in piezocatalytic medicine are discussed and proposed, expecting to fuel the development of this emerging scientific discipline.<\/jats:p>","DOI":"10.1002\/adma.202208256","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T13:48:52Z","timestamp":1673531332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":313,"title":["Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications"],"prefix":"10.1002","volume":"35","author":[{"given":"Si","family":"Chen","sequence":"first","affiliation":[{"name":"Shanghai Tenth People's Hospital, Clinical Center For Brain And Spinal Cord Research Shanghai Frontiers Science Center of Nanocatalytic Medicine The Institute for Biomedical Engineering and Nano Science School of Medicine Tongji University  Shanghai 200092 P. R. 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