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Therefore, it is imperative to develop methods that can efficiently identify and neutralize pathogen species. Phage cocktail therapy utilizes the host specificity of phages to adapt to infect resistant bacteria. However, its low sterilization stability efficiency and lack of imaging units seriously restrict its application. Here, a novel strategy combining the aggregation\u2010induced emission photosensitizer (AIE\u2010PS) TBTCP\u2010PMB with phages through a nucleophilic substitution reaction between benzyl bromide and sulfhydryl groups to remove pathogenic bacteria for sepsis treatment is proposed. This strategy retains the phage's host specificity while possessing AIE\u2010PS characteristics with a fluorescence imaging function and reactive\u00a0oxygen\u00a0species (ROS) for detecting and sterilizing bacteria. This synergetic strategy combining phage cocktail therapy and photodynamic therapy (PDT) shows a strong \u201c1\u00a0+\u00a01\u00a0&gt;\u00a02\u201d bactericidal efficacy and superior performance in sepsis mouse models with good biocompatibility. Furthermore, the strategy can quickly diagnose blood infections of clinical blood samples. This simple and accurate strategy provides a promising therapeutic platform for rapid pathogen detection and point\u2010of\u2010care diagnosis. Moreover, it presents a new method for expanding the library of antibacterial drugs to develop new strain identification and improve infectious disease treatment, thereby demonstrating strong translational potential.<\/jats:p>","DOI":"10.1002\/adma.202208578","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T06:19:21Z","timestamp":1669616361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Engineered Phage with Aggregation\u2010Induced Emission Photosensitizer in Cocktail Therapy against Sepsis"],"prefix":"10.1002","volume":"35","author":[{"given":"Ming\u2010Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery TaiKang Center for Life and Medical Sciences Zhongnan Hospital of Wuhan University School of Pharmaceutical Sciences Wuhan University  Wuhan Hubei 430071 P. 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