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Herein, an ultra\u2010small nano\u2010photosensitizer\n                    <jats:bold>1a<\/jats:bold>\n                    with excellent tumor\u2010specific accumulation and renal clearance is reported. It is formed from the self\u2010assembly of compound\n                    <jats:bold>1<\/jats:bold>\n                    bearing three triethylene glycol (TEG) arms\u00a0and two pyridinium groups in water. The positively charged surface with neutral TEG coating enables\n                    <jats:bold>1a<\/jats:bold>\n                    to efficiently target the tumor, with the signal\u2010to\u2010background ratio reaching as high as 11.5 after tail intravenous injection. The ultra\u2010small size of\n                    <jats:bold>1a<\/jats:bold>\n                    with an average diameter of 5.6\u00a0nm allows its fast clearance through kidney. Self\u2010assembly also endows\n                    <jats:bold>1a<\/jats:bold>\n                    with an 18.2\u2010fold enhancement of reactive oxygygen species generation rate compared to compound\n                    <jats:bold>1<\/jats:bold>\n                    in organic solution. Nano\u2010PS\n                    <jats:bold>1a<\/jats:bold>\n                    manifests an excellent photodynamic therapy efficacy on tumor\u2010bearing mouse models. This work provides a promising design strategy of photosensitizers with renal clearable and tumor\u2010targeting ability.\n                  <\/jats:p>","DOI":"10.1002\/adma.202209789","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T03:16:56Z","timestamp":1677727016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Ultra\u2010Small Nano\u2010Assemblies as Tumor\u2010Targeted and Renal Clearable Theranostic Agent for Photodynamic Therapy"],"prefix":"10.1002","volume":"35","author":[{"given":"Dongsheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals Ministry of Education College of Chemistry Beijing Normal University  Beijing 100875 P. R. 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