{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:21:09Z","timestamp":1786976469773,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["21JCYBJC00660"],"award-info":[{"award-number":["21JCYBJC00660"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019005","name":"Young Elite Scientists Sponsorship Program by Tianjin","doi-asserted-by":"publisher","award":["0701320001"],"award-info":[{"award-number":["0701320001"]}],"id":[{"id":"10.13039\/501100019005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption, and tight junction (TJ) proteins loss. Excess of H\n                    <jats:sub>2<\/jats:sub>\n                    S in the intestinal milieu produced by the\u00a0sulfate\u2010reducing bacteria metabolism contributes to\u00a0development of\u00a0IBDs via epithelial barrier breakdown. Conventional interventions, such as surgery and anti\u2010inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)\u2010based polymer\u2010coated Zr\u2010based metal\u2013organic framework (UiO\u201066) with a Cu\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010rhodamine B (CR) probe (hereinafter referred to as HUR), is produced via\u00a0a\u00a0co\u2010flow microfluidic approach with the ability to reduce H\n                    <jats:sub>2<\/jats:sub>\n                    S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO\u201066@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration, and TJ proteins upregulation via H\n                    <jats:sub>2<\/jats:sub>\n                    S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR is verified to be a promising theranostic platform able to decrease the H\n                    <jats:sub>2<\/jats:sub>\n                    S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202210047","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T13:21:00Z","timestamp":1673616060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Orally Administrable H\n                    <sub>2<\/sub>\n                    S\u2010Scavenging Metal\u2013Organic Framework Prepared by Co\u2010Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu"],"prefix":"10.1002","volume":"35","author":[{"given":"Yunsheng","family":"Dou","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Drug Delivery &amp; High\u2010Efficiency School of Pharmaceutical Science and Technology Tianjin University  Tianjin 300072 P. R. 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