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However, existing fluorescent probes cannot meet the clinical needs because of inevitable photobleaching properties. Performance can be improved by maintaining intensive and sustained fluorescence signals via resistance to intraoperative saline flushing and intrinsic fluorescent decay, providing surgeons with sufficiently clear and high\u2010contrast surgical fields, avoiding residual tumors or missed diagnosis. This study designs and synthesizes a photostable cascade\u2010activatable peptide, a target reaction\u2010induced aggregation peptide (TRAP) system, which can construct polypeptide\u2010based nanofibers in situ on the cell membrane to achieve long\u2010term and stable imaging of bladder cancer. The probe has two parts: a target peptide (TP) targets CD44v6 to recognize bladder cancer cells, and a reaction\u2010induced aggregation peptide (RAP) is introduced, which effectively reacts with the TP via a click reaction to enhance the hydrophobicity of the whole molecule, assembling into nanofibers and further nanonetworks. Accordingly, probe retention on the cell membrane is prolonged, and photostability is significantly improved. Finally, the TRAP system is successfully employed in the high\u2010performance identification of human bladder cancer in ex vivo bladder tumor tissues. This cascade\u2010activatable peptide molecular probe based on the TRAP system enables efficient and stable imaging of bladder cancer.<\/jats:p>","DOI":"10.1002\/adma.202210732","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T20:33:07Z","timestamp":1683923587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Photostable Cascade\u2010Activatable Peptide Self\u2010Assembly on a Cancer Cell Membrane for High\u2010Performance Identification of Human Bladder Cancer"],"prefix":"10.1002","volume":"35","author":[{"given":"Ziqi","family":"Wang","sequence":"first","affiliation":[{"name":"NHC and CAMS Key Laboratory of Molecular Probes and Targeted Theranostics Harbin Medical University  Harbin 150001 China"},{"name":"Department of Urology Harbin Medical University Cancer Hospital  Harbin 150081 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