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To tackle this problem, a VDA\u2010free biomimetic semiconducting polymer nanoparticle (SPN<jats:sub>P<\/jats:sub>) is herein reported for precise tumor vascular disruption through two\u2010stage light manipulation. SPN<jats:sub>P<\/jats:sub> consists of a semiconducting polymer nanoparticle as the photothermal agent camouflaged with platelet membranes that specifically target disrupted vasculature. Upon the first photoirradiation, SPN<jats:sub>P<\/jats:sub> administered in vivo generates mild hyperthermia to trigger tumor vascular hemorrhage, which activates the coagulation cascade and recruits more SPN<jats:sub>P<\/jats:sub> to injured blood vessels. Such enhanced tumor vascular targeting of photothermal agents enables intense hyperthermia to destroy the tumor vasculature during the second photoirradiation, leading to complete tumor eradication and efficient metastasis inhibition. Intriguingly, the mechanism study reveals that this vascular disruption strategy alleviates splenomegaly and reverses the immunosuppressive tumor microenvironment by reducing myeloid\u2010derived suppressor cells. Therefore, this study not only illustrates a light\u2010driven self\u2010recruitment strategy to enhance tumor vascular disruption via a single dose of biomimetic therapeutics but also deciphers the immunotherapeutic role of vascular disruption therapy that is conducive to clinical studies.<\/jats:p>","DOI":"10.1002\/adma.202210920","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T05:32:30Z","timestamp":1679290350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Light\u2010Driven Self\u2010Recruitment of Biomimetic Semiconducting Polymer Nanoparticles for Precise Tumor Vascular Disruption"],"prefix":"10.1002","volume":"35","author":[{"given":"Haoze","family":"Li","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of High Performance Polymer Materials and Technology and Department of Polymer Science &amp; Engineering College of Chemistry &amp; Chemical Engineering Nanjing University  Nanjing 210023 P. 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