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Several gastrointestinal diseases such as reflux disease, Crohn's disease, irritable bowel syndrome, and eosinophilic esophagitis result in increased intercellular dilation in epithelial barriers. Currently, the primary method of diagnosing and monitoring epithelial barrier integrity is via endoscopic tissue biopsies followed by histological imaging. Here, a gelatin\u2010based ingestible electronic capsule that can monitor epithelial barriers via electrochemical impedance measurements is proposed. Toward this end, material\u2010specific transfer printing methodologies to manufacture soft\u2010gelatin\u2010based electronics, an in vitro synthetic disease model to validate impedance\u2010based sensing, and tests of capsules using ex vivo using porcine esophageal tissue are described. 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