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These injuries are particularly challenging therapeutically because of variable nerve diameters, slow axonal regeneration, infection of severed ends, fragility of the nerve tissue, and the intricacy of surgical intervention. Surgical suturing is likely to cause additional damage to peripheral nerves. Therefore, an ideal nerve scaffold should possess good biocompatibility, diameter adaptability, and a stable biological interface for seamless biointegration with tissues. Inspired by the curl of <jats:italic>Mimosa pudica<\/jats:italic>, this study aimed to design and develop a diameter\u2010adaptable, suture\u2010free, stimulated curling bioadhesive tape (SCT) hydrogel for repairing PNI. The hydrogel is fabricated from chitosan and acrylic acid\u2010N\u2010hydroxysuccinimide lipid via gradient crosslinking using glutaraldehyde. It closely matches the nerves of different individuals and regions, thereby providing a bionic scaffold for axonal regeneration. In addition, this hydrogel rapidly absorbs tissue fluid from the nerve surface achieving durable wet\u2010interface adhesion. Furthermore, the chitosan\u2010based SCT hydrogel loaded with insulin\u2010like growth factor\u2010I effectively promotes peripheral nerve regeneration with excellent bioactivity. This procedure for peripheral nerve injury repair using the SCT hydrogel is simple and reduces the difficulty and duration of surgery, thereby advancing adaptive biointerfaces and reliable materials for nerve repair.<\/jats:p>","DOI":"10.1002\/adma.202212015","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T14:24:51Z","timestamp":1684506291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Mimosa\u2010Inspired Stimuli\u2010Responsive Curling Bioadhesive Tape Promotes Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"35","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma Peking University People's Hospital Key Laboratory of Trauma and Neural Regeneration (Peking University) Ministry of Education National Center for Trauma Medicine  Beijing 100044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"An","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research Institute School of Chemistry &amp; Biological Engineering University of Science and Technology Beijing  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Gu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research Institute School of Chemistry &amp; Biological Engineering University of Science and Technology Beijing  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research Institute School of Chemistry &amp; Biological Engineering University of Science and Technology Beijing  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengshi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Peking University People's Hospital Key Laboratory of Trauma and Neural Regeneration (Peking University) Ministry of Education National Center for Trauma Medicine  Beijing 100044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Guo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Peking University People's Hospital Key Laboratory of Trauma and Neural Regeneration (Peking University) Ministry of Education National Center for Trauma Medicine  Beijing 100044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research Institute School of Chemistry &amp; Biological Engineering University of Science and Technology Beijing  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7200-2281","authenticated-orcid":false,"given":"Peixun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Peking University People's Hospital Key Laboratory of Trauma and Neural Regeneration (Peking University) Ministry of Education National Center for Trauma Medicine  Beijing 100044 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm3291"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13695-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02598-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202000225"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.36272"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103875"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2019.01.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000604"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.05.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120982"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368916X690836"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.008"},{"key":"e_1_2_8_13_1","first-page":"28","author":"Grasman J. 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