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Notably, singlet diradicals exhibit tunable redox amphoterism, which makes them excellent redox\u2010active materials for biomedical applications. However, the safety and therapeutic efficacy of singlet diradicals in biological systems have not yet been explored. Herein, the study presents a newly designed singlet diradical nanomaterial, diphenyl\u2010substituted biolympicenylidene (BO\u2010Ph), exhibiting low cytotoxicity in vitro, non\u2010significant acute nephrotoxicity in vivo, and the ability to induce metabolic reprogramming in kidney organoids. Integrated transcriptome and metabolome analyses reveal that the metabolism of BO\u2010Ph stimulates glutathione (GSH) synthesis and fatty acid degradation, increases the levels of intermediates in the tricarboxylic acid (TCA) and carnitine cycles, and eventually boosts oxidative phosphorylation (OXPHOS) under redox homeostasis. Benefits of BO\u2010Ph\u2010induce metabolic reprogramming in kidney organoids include enhancing cellular antioxidant capacity and promoting mitochondrial function. The results of this study can facilitate the application of singlet diradical materials in the treatment of clinical conditions induced by mitochondrial abnormalities in kidney.<\/jats:p>","DOI":"10.1002\/adma.202301338","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T18:19:18Z","timestamp":1686334758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Induction of Metabolic Reprogramming in Kidney by Singlet Diradical Nanoparticles"],"prefix":"10.1002","volume":"35","author":[{"given":"Lei","family":"Ye","sequence":"first","affiliation":[{"name":"Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Tsinghua\u2010Berkeley Shenzhen Institute Tsinghua 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