{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:06:42Z","timestamp":1789531602751,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"35","license":[{"start":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T00:00:00Z","timestamp":1689724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["SKJY2021047"],"award-info":[{"award-number":["SKJY2021047"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ym0126808"],"award-info":[{"award-number":["JP22ym0126808"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Boron neutron capture therapy (BNCT) has emerged as a treatment modality with high precision and efficacy of intractable tumors. At the core of effective tumor BNCT are\n                    <jats:sup>10<\/jats:sup>\n                    B carriers with facile preparation as well as advantageous pharmacokinetic and therapeutic profiles. Herein, the design and preparation of sub\u201010 nm\u00a0\n                    <jats:sup>10<\/jats:sup>\n                    B\u2010enriched hexagonal boron nitride nanoparticles grafted with poly(glycerol) (h\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN\u2010PG), and their application to cancer treatment by BNCT are reported. By virtue of their small particle size and outstanding stealth property, h\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN\u2010PG nanoparticles accumulate efficiently in murine CT26 colon tumors with a high intratumor\n                    <jats:sup>10<\/jats:sup>\n                    B concentration of 8.8%ID\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    or 102.1\u00a0\u00b5g\u00a0g\n                    <jats:sup>\u22121<\/jats:sup>\n                    at 12\u00a0h post\u2010injection. Moreover, h\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN\u2010PG nanoparticles penetrate into the inside of the tumor parenchyma and then are taken up by the tumor cells. BNCT comprising a single bolus injection of h\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN\u2010PG nanoparticles and subsequent one\u2010time neutron irradiation results in significant shrinkage of subcutaneous CT26 tumors. h\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN\u2010PG\u2010mediated BNCT not only causes direct DNA damage to the tumor cells, but also triggers pronounced inflammatory immune response in the tumor tissues, which contributes to long\u2010lasting tumor suppression after the neutron irradiation. Thus, the h\u2010\n                    <jats:sup>10<\/jats:sup>\n                    BN\u2010PG nanoparticles are promising BNCT agents to eradicate tumor through highly efficient\n                    <jats:sup>10<\/jats:sup>\n                    B accumulation.\n                  <\/jats:p>","DOI":"10.1002\/adma.202301479","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T11:18:58Z","timestamp":1685186338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Tumor Eradication by Boron Neutron Capture Therapy with\n                    <sup>10<\/sup>\n                    B\u2010enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(Glycerol)"],"prefix":"10.1002","volume":"35","author":[{"given":"Yucai","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heon Gyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University  Sakyo\u2010ku Kyoto 606\u20138501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010zhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan University  Donghu Avenue No.185 Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Institute for Integrated Radiation and Nuclear Science Kyoto University  2\u20131010 Asashiro\u2010nishi, Kumatori\u2010cho Sennan\u2010gun Osaka 590\u20100494 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Soochow University  Suzhou 215004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan University  Donghu Avenue No.185 Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Graduate School of Human and Environmental Studies Kyoto University  Sakyo\u2010ku Kyoto 606\u20138501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-3055","authenticated-orcid":false,"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and Protection &amp; School for Radiological and Interdisciplinary Sciences (RAD\u2010X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University  Suzhou Jiangsu 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2019.109029"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/life11040330"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.601820"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01480-4"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01304-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121861"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29780-w"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101558"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0141"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-018-0299-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz1722"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.02.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700850"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04303"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202204044"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100969"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201601238"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2019.126832"},{"key":"e_1_2_8_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120587"},{"key":"e_1_2_8_11_4","doi-asserted-by":"publisher","DOI":"10.1021\/nn1006495"},{"key":"e_1_2_8_11_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.11.020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606628"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2017.09.151"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2013.01.070"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2020.05.041"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2015.06.004"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/nl504397h"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201305256"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201304298"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201201060"},{"key":"e_1_2_8_17_3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00615"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006310"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.10.64"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02289"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00600-w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2019.01.012"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01988A"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201901930"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.01.007"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/374252"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c00895"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.09.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2011.166"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114614"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2014.03.003"},{"key":"e_1_2_8_31_1","first-page":"305","volume":"22","author":"Kuo L. 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