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Ta, as a medical metal element, has been widely used in the treatment of different diseases because of its excellent physicochemical properties but is still far from being explored in IBD. Here, Ta\n                    <jats:sub>2<\/jats:sub>\n                    C modified with chondroitin sulfate (CS) (TACS) is evaluated as a highly targeted therapy nanomedicine for IBD. Specifically, TACS is modified with dual targeting CS functions due to IBD lesion\u2010specific positive charges and high expression of CD44 receptors. Thanks to the acid stability, sensitive CT imaging function, and strong reactive oxygen species (ROS) elimination ability, oral TACS can accurately locate and delineate IBD lesions through non\u2010invasive CT imaging, and specifically targeted treat IBD effectively because high levels of ROS are a central factor in the progression of IBD. As expected, TACS has much better imaging and therapeutic effects than clinical CT contrast agent and first\u2010line drug 5\u2010aminosalicylic acid, respectively. The mechanism of TACS treatment mainly involves protection of mitochondria, elimination of oxidative stress, inhibiting macrophage M1 polarization, protection of intestinal barrier, and restoration of intestinal flora balance. Collectively, this work provides unprecedented opportunities for oral nanomedicines to targeted therapy of IBD.\n                  <\/jats:p>","DOI":"10.1002\/adma.202301585","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T12:45:11Z","timestamp":1684932311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta\n                    <sub>2<\/sub>\n                    C Modified with Chondroitin Sulfate (TACS)"],"prefix":"10.1002","volume":"35","author":[{"given":"Xiangping","family":"Song","sequence":"first","affiliation":[{"name":"Department of Geriatric Surgery Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"Xiangya School of Pharmaceutical Sciences Central South University  Changsha 410008 China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"Department of General Surgery Xiangya Hospital Central South University  Changsha 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha 410008 China"},{"name":"Department of Pharmacy, Xiangya Hospital Central South University  Changsha 410008 P. 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