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However, in vivo delivery suffers from non\u2010specific distribution in non\u2010targeted organs or tissues, which may cause undesired side effects and even genotoxicity. Here, a general strategy that enables tuning the tropism of polymersomes for liver\u2010 and spleen\u2010selective delivery is reported. By using a library screening approach, spleen\u2010targeted polymersome PH9\u2010Aln\u20108020 and liver\u2010targeted polymersome PA9\u2010ZP3\u20105050 are identified accordingly. Meanwhile, the second near\u2010infrared (NIR\u2010II) fluorescence imaging allows for in vivo dynamic evaluation of their spatial and temporal accumulation in specific tissues. O ur findings indicate that both polymer composition and protein corona on the surface are essential to determine the in vivo fate of polymersomes and tendency for specific organs. Importantly, PH9\u2010Aln\u20108020 is employed as a systemic nanocarrier to co\u2010deliver the antigen and adjuvant, which remarkably boost splenic immune responses in acute myeloid leukemia, melanoma, and melanoma lung metastasis mouse models. This study may open a new frontier for polymersomes in organ\u2010selective delivery and other biomedical applications.<\/jats:p>","DOI":"10.1002\/adma.202301686","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T03:59:54Z","timestamp":1683777594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tuning the Organ Tropism of Polymersome for Spleen\u2010Selective Nanovaccine Delivery to Boost Cancer Immunotherapy"],"prefix":"10.1002","volume":"35","author":[{"given":"Wenxing","family":"Gu","sequence":"first","affiliation":[{"name":"Institute of Precision Medicine Peking University Shenzhen Hospital  Shenzhen 518036 P. R. 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