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Activation of endogenous NSCs, is attracting increasing research enthusiasm, which avoids immune rejection and ethical issues of exogenous cell transplantation. Yet, how to induce directed growth and differentiation in situ remain a major challenge. In this study, a pure water\u2010driven Ni\u2013Zn micromotor via a self\u2010established electric\u2013chemical field is proposed. The micromotors can be magnetically guided and precisely approach target NSCs. Through the electric\u2013chemical field, bioelectrical signal exchange and communication with endogenous NSCs are allowed, thus allowing for regulated proliferation and directed neuron differentiation in vivo. 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