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It may provide a diverse and robust toolbox for surgeons to integrate wound microenvironment with much safer and stronger hemostatic capacity than conventional materials and hemostatic agents. Especially in noncompressible torso hemorrhage (NCTH), diffuse mucosal surface bleeding, and internal medical bleeding (IMB), with respect to the optimal hemostatic formulation, dSAP biomaterials are the ingenious nanofiber alternatives to make bioactive neural scaffold, nasal packing, large mucosal surface coverage in gastrointestinal surgery (esophagus, gastric lesion, duodenum, and lower digestive tract), epicardiac cell\u2010delivery carrier, transparent matrix barrier, and so on. Herein, in multiple surgical specialties, dSAP\u2010biomaterial\u2010based nano\u2010hemostats achieve safe, effective, and immediate hemostasis, facile wound healing, and potentially reduce the risks in delayed bleeding, rebleeding, post\u2010operative bleeding, or related complications. The biosafety in vivo, bleeding indications, tissue\u2010sealing quality, surgical feasibility, and local usability are addressed comprehensively and sequentially and pursued to develop useful surgical techniques with better hemostatic performance. Here, the state of the art and all\u2010round advancements of nano\u2010hemostatic approaches in surgery are provided. Relevant critical insights will inspire exciting investigations on peptide nanotechnology, next\u2010generation biomaterials, and better promising prospects in clinics.<\/jats:p>","DOI":"10.1002\/adma.202301849","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T08:12:49Z","timestamp":1679386369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Short Peptide Nanofiber Biomaterials Ameliorate Local Hemostatic Capacity of Surgical Materials and Intraoperative Hemostatic Applications in Clinics"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-4082","authenticated-orcid":false,"given":"Zehong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology West China School of Basic Medical Sciences and Forensic Medicine Sichuan University  Chengdu Sichuan 610041 China"},{"name":"Institute for 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