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However, excessive inflammatory macrophages are also recruited simultaneously, aggravating myocardial damage. More seriously, the increased inflammation contributes to abnormal cardiomyocyte electrical coupling, leading to inhomogeneities in ventricular conduction and retarded conduction velocity. It is highly desirable to selectively recruit the stem cells but block the inflammation. In this work, SDF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010encapsulated Puerarin (PUE) hydrogel (SDF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    @PUE) is capable of enhancing endogenous stem cell homing and simultaneously polarizing the recruited monocyte\/macrophages into a repairing phenotype. Flow cytometry analysis of the treated heart tissue shows that endogenous bone marrow mesenchymal stem cells, hemopoietic stem cells, and immune cells are recruited while SDF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    @PUE efficiently polarizes the recruited monocytes\/macrophages into the M2 type. These macrophages influence the preservation of connexin 43 (Cx43) expression which modulates intercellular coupling and improves electrical conduction. Furthermore, by taking advantage of the improved \u201csoil\u201d, the recruited stem cells mediate an improved cardiac function by preventing deterioration, promoting neovascular architecture, and reducing infarct size. These findings demonstrate a promising therapeutic platform for MI that not only facilitates heart regeneration but also reduces the risk of cardiac arrhythmias.\n                  <\/jats:p>","DOI":"10.1002\/adma.202302686","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T15:24:02Z","timestamp":1693841042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Pericardial Delivery of SDF\u20101\n                    <i>\u03b1<\/i>\n                    Puerarin Hydrogel Promotes Heart\u00a0Repair and Electrical Coupling"],"prefix":"10.1002","volume":"36","author":[{"given":"Li","family":"Luo","sequence":"first","affiliation":[{"name":"The Tenth Affiliated Hospital of Southern Medical University  Dongguan Guangdong 523059 China"},{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou Guangdong 510515 China"},{"name":"Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetong","family":"Li","sequence":"additional","affiliation":[{"name":"The Tenth Affiliated Hospital of Southern Medical University  Dongguan Guangdong 523059 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Bao","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences North Carolina State University  Raleigh NC 27606 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqin","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiology Department of Panyu Central Hospital and Cardiovascular Disease Institute of Panyu District  Guangzhou 511400 P. 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