{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:22:05Z","timestamp":1786976525779,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC51973180"],"award-info":[{"award-number":["NSFC51973180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["7020028"],"award-info":[{"award-number":["7020028"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["7005949"],"award-info":[{"award-number":["7005949"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["9231412"],"award-info":[{"award-number":["9231412"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["9231486"],"award-info":[{"award-number":["9231486"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Catechins from green tea are one of the most effective natural compounds for cancer chemoprevention and have attracted extensive research. Cancer cell\u2010selective apoptosis\u2010inducing properties of catechins depend on efficient intracellular delivery. However, the low bioavailability limits the application of catechins. Herein, a nano\u2010scaled micellar composite composed of catechin\u2010functionalized cationic lipopolymer and serum albumin is constructed. Cationic liposomes tend to accumulate in the pulmonary microvasculature due to electrostatic effects and are able to deliver the micellar system intracellularly, thus improving the bioavailability of catechins. Albumin in the system acts as a biocompatible anti\u2010plasma absorbent, forming complexes with positively charged lipopolymer under electrostatic interactions, contributing to prolonged in vivo retention. The physicochemical properties of the nano\u2010micellar complexes are characterized, and the antitumor properties of catechin\u2010functionalized materials are confirmed by reactive oxygen species (ROS), caspase\u20103, and cell apoptosis measurements. The role of each functional module, cationic polymeric liposome, and albumin is revealed by cell penetration, in vivo animal assays, etc. This multicomponent micellar nanocomposite has the potential to become an effective vehicle for the treatment of lung diseases such as pneumonia, lung tumors, sepsis\u2010induced lung injury, etc. This study also demonstrates that it is a great strategy to create a delivery system that is both tissue\u2010targeted and biologically active by combining cationic liposomes with the native bioactive compound catechins.<\/jats:p>","DOI":"10.1002\/adma.202302985","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T21:43:50Z","timestamp":1691617430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Catechin\u2010Functionalized Cationic Lipopolymer Based Multicomponent Nanomicelles for Lung\u2010Targeting Delivery"],"prefix":"10.1002","volume":"36","author":[{"given":"Min","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  83 Tat Chee Avenue Kowloon Hong Kong SAR China"},{"name":"Karolinska Institutet Ming Wai Lau Centre for Reparative Medicine HKSTP  Sha Tin Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  83 Tat Chee Avenue Kowloon Hong Kong SAR China"},{"name":"Karolinska Institutet Ming Wai Lau Centre for Reparative Medicine HKSTP  Sha Tin Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  83 Tat Chee Avenue Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulei","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  83 Tat Chee Avenue Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  83 Tat Chee Avenue Kowloon Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225009 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-1422","authenticated-orcid":false,"given":"Dong\u2010An","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering City University of Hong Kong  83 Tat Chee Avenue Kowloon Hong Kong SAR China"},{"name":"Karolinska Institutet Ming Wai Lau Centre for Reparative Medicine HKSTP  Sha Tin Hong Kong SAR China"},{"name":"Shenzhen Research Institute City University of Hong Kong  Shenzhen 518057 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.07.014"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01805.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.08.035"},{"key":"e_1_2_8_4_1","unstructured":"Z.Jiang J.Zhang Y.Cai J.Huang L.You Catechin Attenuates Traumatic Brain Injury\u2010induced Impairments of Blood\u2010brain."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104172"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2017-2665"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1445762"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1719"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/217304"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.3889"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2899"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/0049825031000108315"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf062816a"},{"key":"e_1_2_8_15_1","first-page":"331","volume":"13","author":"Yadav R.","year":"2014","journal-title":"EXCLI J."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf504603n"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.05.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119902"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.043"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.01.056"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-409X(90)90012-H"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11639"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0485-z"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S142739"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2017.12.001"},{"key":"e_1_2_8_26_1","first-page":"163","volume":"2","author":"Di Gioia S.","year":"2009","journal-title":"Drug Des., Dev. Ther."},{"key":"e_1_2_8_27_1","first-page":"426","volume":"67","author":"Sun X.","year":"2012","journal-title":"Die Pharmazie\u2010An International Journal of Pharmaceutical Sciences"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800876"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc800065f"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007504613351"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.09.047"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.1c01100"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/02652049809006831"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020186505848"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-01017-9"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201301992"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.102"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5b00253"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm900325t"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.118273"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2014.10.013"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2022.2136909"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203597"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.4.611"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.03.120"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2016.04.01"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1645152"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.039"},{"key":"e_1_2_8_50_1","first-page":"3090","volume":"44","author":"Nederman T.","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.01.021"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc000120w"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm025563c"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202814"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0518(19990315)37:6<751::AID-POLA10>3.0.CO;2-0"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01494"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.226"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100095"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23143"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.202302985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:13:56Z","timestamp":1759749236000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.202302985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":59,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/adma.202302985"],"URL":"https:\/\/doi.org\/10.1002\/adma.202302985","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2302985"}}