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Two types of photosensitive neural spheroids are transfected for selective reaction under bluish\u2010purple and green lights. These are employed to two devices with intact neuron and neural\u2010spheroid to study the interaction. By photostimulation, the photosensitive spheroid initiated photoactivation, and the signal generated from its body is transmitted to adjacent neural networks. Specifically, the signal traveled through the axon bundle in narrow gap from photosensitive spheroid to intact spheroid as an eye\u2010to\u2010brain model including optic nerve. The whole process with photosensitive spheroid is monitored by calcium ion detecting fluorescence images. The results of this study can be applied to examine vision restoration and novel photosensitive biological systems with spectral sensitivity.<\/jats:p>","DOI":"10.1002\/adma.202302996","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T07:04:15Z","timestamp":1687935855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eye\u2010Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins"],"prefix":"10.1002","volume":"35","author":[{"given":"Byeongho","family":"Park","sequence":"first","affiliation":[{"name":"Korea Institute of Science and Technology (KIST)  Seoul 02792 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seokyoung","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Dongguk University  Goyang 10326 Republic of 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