{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:48:47Z","timestamp":1791575327225,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073191"],"award-info":[{"award-number":["52073191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51925304"],"award-info":[{"award-number":["51925304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973133"],"award-info":[{"award-number":["51973133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are limited to unilateral efforts in joint lubrication, inhibition of inflammation, free radicals scavenging, and cartilage regeneration. Herein, by modifying molybdenum disulfide (MoS\n                    <jats:sub>2<\/jats:sub>\n                    ) with Mg\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010doped polydopamine and coating with polysulfobetaines, a dual\u2010bionic photothermal nanozyme (MPMP) is constructed to mimic antioxidases\/hyaluronan synthase for OA therapy. Photothermally enhanced lubrication lowers the coefficient of friction (0.028) in the early stage of OA treatment. The antioxidases\u2010mimicking properties of MPMP nanozyme contribute to eliminating reactive oxygen and nitrogen species (ROS\/RNS) (over 90% of scavenging ratio for H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \/\u00b7OH\/O\n                    <jats:sup>\u00b7<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2013<\/jats:sup>\n                    \/DPPH\/ABTS\n                    <jats:sup>+<\/jats:sup>\n                    ) and supplying O\n                    <jats:sub>2<\/jats:sub>\n                    . With NIR irradiation, the MPMP nanozyme triggers thermogenesis (upregulating HSP70 expression) and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    release, which promotes the chondrogenesis in inflammatory conditions by deactivating NF\u2010\u03baB\/IL\u201017 signaling pathways and enhancing MAPK signaling pathway. Benefiting from HSP70 and Mg\n                    <jats:sup>2+<\/jats:sup>\n                    , MPMP\u2010NIR shows HAS\u2010mimicking activity to increase the intracellular (twofold) and extracellular (3.12\u2010fold) HA production. Therefore, MPMP\u2010NIR demonstrates superior spatiotemporally therapeutic effect on OA in mice model, in terms of osteophytes (83.41% of reduction), OARSI scores (88.57% of reduction), and ACAN expression (2.70\u2010fold of increment). Hence, insights into dual\u2010bionic nanozymes can be a promising strategy for OA therapy or other inflammation\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/adma.202303299","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T16:04:05Z","timestamp":1689609845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["Mimicking Antioxidases and Hyaluronan Synthase: A Zwitterionic Nanozyme for Photothermal Therapy of Osteoarthritis"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3363-8911","authenticated-orcid":false,"given":"Peng","family":"Yu","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Kang","sequence":"additional","affiliation":[{"name":"Life Science Core Facilities College of Life Sciences Sichuan University  Chengdu 610065 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiangwei","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University  Chengdu 610065 P. R. 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