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However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water\u2010in\u2010oil Pickering emulsion gel is developed to deliver (1S, 3R)\u2010RSL\u20103 (RSL\u20103), a ferroptosis inducer dissolved in iodized oil, and programmed death\u20101 (PD\u20101) antibody, the most commonly used immune checkpoint inhibitor dissolved in water, with optimal characteristics (RSL\u20103 + PD\u20101@gel). Tumor lipase degrades the continuous oil phase, which results in the slow release of RSL\u20103\u00a0and PD\u20101\u00a0antibody and a notable antitumor effect against low\u2010immunogenic hepatocellular carcinoma and pancreatic cancer. Intriguingly, the RSL\u20103 + PD\u20101@gel induces ferroptosis of tumor cells, resulting in antitumor immune response via accumulation of helper T lymphocyte cells and cytotoxic T cells. Additionally, the single\u2010cell sequence profiling analysis during tumor treatment reveals the induction of ferroptosis in tumor cells together with strong antitumor immune response in ascites.<\/jats:p>","DOI":"10.1002\/adma.202303542","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T17:43:37Z","timestamp":1684259017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Induction of Tumor Ferroptosis\u2010Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel"],"prefix":"10.1002","volume":"35","author":[{"given":"Xiaomeng","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University  #79 Qingchun Road Hangzhou Zhejiang Province 310003 P. R. 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